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IWP-2

CAT: 1568-C12427-03Size: 1 gDry Ice: YesHazardous: No
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CAT#:1568-C12427-03Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
686770-61-6
SKU
C12427-10mg
Target
Wnt/beta-catenin
Applications
Cytoskeletal Signaling
Smiles
CC1=CC2=C (C=C1) N=C (S2) NC (=O) CSC3=NC4=C (C (=O) N3C5=CC=CC=C5) SCC4
Molecular Formula
C22H18N4O2S3
Additionnal Information
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.
Storage Conditions
2 years -80 in solvent

Chemical Information

Iwp-2

IWP-2 is a thienopyridine that is 6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one substituted by {2-[(6-methyl-1,3-benzothiazol-2-yl)amino]-2-oxoethyl}sulfanediyl and phenyl groups at positions 2 and 3, respectively. It is an ATP-competitive CK1delta inhibitor and also a Wnt/beta-catenin signal pathway inhibitor. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and a Wnt signalling inhibitor. It is a secondary carboxamide, an organic sulfide, a member of benzenes, a thienopyridine and a member of benzothiazoles.

CAS Number686770-61-6
PubChem CID2155128
IUPAC NameN-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
Molecular FormulaC22H18N4O2S3
Molecular Weight466.6
XLogP4.8
Topological Polar Surface Area154
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity796
SMILES
CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4
InChI
InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
InChIKey
WRKPZSMRWPJJDH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Iwp-2
CAS: 686770-61-6
CID: 2155128
Formula: C22H18N4O2S3
MW: 466.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight466.6
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass466.05918935
Monoisotopic Mass466.05918935
Topological Polar Surface Area154 Ų
Heavy Atom Count31
Formal Charge0
Complexity796
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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