NE 52-QQ57

CAT: 1568-C12269-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:1568-C12269-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1401728-56-0
SKU
C12269-5mg
Target
GPR
Applications
GPCR & G Protein
Smiles
CCC1=NN2C (=CC (=NC2=C1CC3=CC=C (C=C3) C4=NN=C (O4) C5CCNCC5) C) C
Molecular Formula
C24H28N6O
Additionnal Information
NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL) -1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2) .
Storage Conditions
3 years -20°C powder

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