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ICCB-19 hydrochloride

CAT: 1568-C11596-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C11596-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1803605-68-6
SKU
C11596-5mg
Target
RIP kinase
Applications
Apoptosis
Smiles
Cl.O=C (CSC1=NCCN1) NC2CCCCCC2
Molecular Formula
C12H22ClN3OS
Additionnal Information
ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) . ICCB-19 effectively induces autophagy.
Storage Conditions
3 years -20°C powder

Chemical Information

N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide hydrochloride
CAS Number1803605-68-6
PubChem CID91654402
IUPAC NameN-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide;hydrochloride
Molecular FormulaC12H22ClN3OS
Molecular Weight291.84
Topological Polar Surface Area78.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count18
Formal Charge0
Complexity285
SMILES
C1CCCC(CC1)NC(=O)CSC2=NCCN2.Cl
InChI
InChI=1S/C12H21N3OS.ClH/c16-11(9-17-12-13-7-8-14-12)15-10-5-3-1-2-4-6-10;/h10H,1-9H2,(H,13,14)(H,15,16);1H
InChIKey
TZICOTBZKPHMMK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide hydrochloride
CAS: 1803605-68-6
CID: 91654402
Formula: C12H22ClN3OS
MW: 291.84
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight291.84
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass291.1172112
Monoisotopic Mass291.1172112
Topological Polar Surface Area78.8 Ų
Heavy Atom Count18
Formal Charge0
Complexity285
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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