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Cediranib Maleate

CAT: 1568-C10837Size: 10 mgDry Ice: NoHazardous: No
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CAT#:1568-C10837Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
857036-77-2
Synonyms
AZD2171 maleate
SKU
C10837-10mg
Target
VEGFR
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC2=C (N1) C=CC (=C2F) OC3=NC=NC4=CC (=C (C=C43) OC) OCCCN5CCCC5.C (=CC (=O) O) C (=O) O
Molecular Formula
C25H27FN4O3.C4H4O4
Additionnal Information
Cediranib Maleate (AZD2171) is the maleate salt of Cediranib, which is a potent inhibitor of VEGFR with IC50 of <1 nM and also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.
Storage Conditions
3 years -20°C powder

Chemical Information

Cediranib Maleate

Cediranib Maleate is the maleate salt of an indole ether quinazoline derivative with antineoplastic activities. Competing with adenosine triphosphate, cediranib binds to and inhibits all three vascular endothelial growth factor receptor (VEGFR-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.

CAS Number857036-77-2
PubChem CID11226834
IUPAC Name(Z)-but-2-enedioic acid;4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline
Molecular FormulaC29H31FN4O7
Molecular Weight566.6
Topological Polar Surface Area147
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count10
Heavy Atom Count41
Formal Charge0
Complexity743
SMILES
CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5.C(=C\C(=O)O)\C(=O)O
InChI
InChI=1S/C25H27FN4O3.C4H4O4/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30;5-3(6)1-2-4(7)8/h6-7,12-15,29H,3-5,8-11H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey
JRMGHBVACUJCRP-BTJKTKAUSA-N
Chemical Structure
2D Structure
2D structure of Cediranib Maleate
CAS: 857036-77-2
CID: 11226834
Formula: C29H31FN4O7
MW: 566.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight566.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count10
Exact Mass566.21767750
Monoisotopic Mass566.21767750
Topological Polar Surface Area147 Ų
Heavy Atom Count41
Formal Charge0
Complexity743
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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