LY2409881 (trihydrochloride)
CAT:
804-HY-B0788A-01
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
LY2409881 (trihydrochloride)
- CAS Number: 946518-60-1
- UNSPSC Description: LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.
- Target Antigen: Apoptosis; IKK
- Type: Reference compound
- Related Pathways: Apoptosis;NF-κB
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/LY2409881-trihydrochloride.html
- Purity: 98.14
- Solubility: DMSO : 14.29 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(C1=C(C=C(C2=NC(NCCCN3CCN(C)CC3)=NC=C2Cl)S4)C4=CC=C1)NC5CC5.[H]Cl.[H]Cl.[H]Cl
- Molecular Weight: 594.43
- References & Citations: [1]Deng C, et al. The novel IKK2 inhibitor LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-κB. Clin Cancer Res. 2015 Jan 1;21(1):134-45.Cell Rep. 2024 Oct 8;43(10):114827.|Clin Transl Med. 2022 Jun;12(6):e850.|Int J Mol Sci. 2023, 24(1), 320.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported