BI-D1870

• CAS Number :

  501437-28-1

• SKU :

  C08901-5mg

• Target :

  S6 Kinase

• Applications :

  MAPK

• Smiles :

  CC1C (=O) N (C2=CN=C (N=C2N1CCC (C) C) NC3=CC (=C (C (=C3) F) O) F) C

• Molecular Formula :

  C19H23F2N5O2

• Additionnal Information :

  BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.

• Storage Conditions :

  2 years -80 in solvent