Bemcentinib (R428)

• CAS Number :

  1037624-75-1

• Synonyms :

  BGB324

• SKU :

  C08899-1mg

• Target :

  Axl

• Applications :

  Protein Tyrosine Kinase

• Smiles :

  C1CCN (C1) C2CCC3=C (CC2) C=C (C=C3) NC4=NN (C (=N4) N) C5=NN=C6C (=C5) CCCC7=CC=CC=C76

• Molecular Formula :

  C30H34N8

• Additionnal Information :

  Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective) .

• Storage Conditions :

  2 years -80 in solvent