Crenolanib

CAT: 1568-C08810-01Size: 5 mgDry Ice: YesHazardous: No
CAT#:1568-C08810-01Size:5 mg
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CAS Number
670220-88-9
Synonyms
CP-868596, ARO 002
SKU
C08810-5mg
Target
PDGFR
Applications
Protein Tyrosine Kinase
Smiles
CC1 (COC1) COC2=CC3=C (C=C2) N (C=N3) C4=NC5=C (C=CC=C5N6CCC (CC6) N) C=C4
Molecular Formula
C26H29N5O2
Additionnal Information
Crenolanib is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.
Storage Conditions
2 years -80 in solvent

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