ENMD-2076

• CAS Number :

  934353-76-1

• SKU :

  C07590-5mg

• Target :

  Aurora Kinase

• Applications :

  Cell Cycle

• Smiles :

  CC1=CC (=NN1) NC2=CC (=NC (=N2) C=CC3=CC=CC=C3) N4CCN (CC4) C

• Molecular Formula :

  C21H25N7

• Additionnal Information :

  ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM, which induces apoptosis and G2/M phase arrest. Phase 2.

• Storage Conditions :

  2 years -80 in solvent