Regorafenib

• CAS Number :

  755037-03-7

• Synonyms :

  Fluoro-Sorafenib, BAY 73-4506

• SKU :

  C07587-5mg

• Target :

  C-RET

• Applications :

  Protein Tyrosine Kinase

• Smiles :

  CNC (=O) C1=NC=CC (=C1) OC2=CC (=C (C=C2) NC (=O) NC3=CC (=C (C=C3) Cl) C (F) (F) F) F

• Molecular Formula :

  C21H15ClF4N4O3

• Additionnal Information :

  Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy.

• Storage Conditions :

  2 years -80 in solvent