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SB202190

CAT: 1568-C07497-02Size: 10 mM / 1 mLDry Ice: YesHazardous: No
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CAT#:1568-C07497-02Size:10 mM / 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
152121-30-7
Synonyms
FHPI
SKU
C07497-25mg
Target
P38 MAPK
Applications
MAPK
Smiles
C1=CC (=CC=C1C2=NC (=C (N2) C3=CC=NC=C3) C4=CC=C (C=C4) F) O
Molecular Formula
C20H14N3OF
Additionnal Information
SB202190 is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin‐dependent ferroptosis.
Storage Conditions
2 years -80 in solvent

Chemical Information

Sb-202190

SB-202190 is a member of the class of imidazoles that is 1H-imidazole in which the hydrogens at positions 2, 4, and 5 are replaced by 4-hydroxyphenyl, pyridin-4-yl, and 4-fluorophenyl groups, respectively. It is a widely used inhibitor of mitogen-activated protein kinase (MAPK) alpha and beta. It has a role as an apoptosis inducer and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a member of imidazoles, a member of pyridines, a member of phenols and an organofluorine compound.

CAS Number152121-30-7
PubChem CID5169
IUPAC Name4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol
Molecular FormulaC20H14FN3O
Molecular Weight331.3
XLogP3.7
Topological Polar Surface Area61.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity415
SMILES
C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O
InChI
InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
InChIKey
QHKYPYXTTXKZST-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Sb-202190
CAS: 152121-30-7
CID: 5169
Formula: C20H14FN3O
MW: 331.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight331.3
XLogP33.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass331.11209024
Monoisotopic Mass331.11209024
Topological Polar Surface Area61.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity415
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS808173-01SB202190
A1632-SSB202190 (FHPI)
ALX-270-268-M005SB202190 . hydrochloride
sc-222294SB202190 hydrochloride
SC0380-10mMSB202190 (p38 MAPK inhibitor)
PB180610SB202190 Solution (100 mM)
MBS6023840-01SB202190 (FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole)
045271-01SB202190 (FHPI, 4- (4-Fluorophenyl) -2- (4-hydroxyphenyl) -5- (4-pyridyl) -1H-imidazole)

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