Sunitinib malate

• CAS Number :

  341031-54-7

• Synonyms :

  SU11248 malate

• SKU :

  C07463-100mg

• Target :

  C-Kit

• Applications :

  Protein Tyrosine Kinase

• Smiles :

  CCN (CC) CCNC (=O) C1=C (NC (=C1C) C=C2C3=C (C=CC (=C3) F) NC2=O) C.C (C (C (=O) O) O) C (=O) O

• Molecular Formula :

  C22H27FN4O2.C4H6O5

• Additionnal Information :

  Sunitinib malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.

• Storage Conditions :

  2 years -80 in solvent