Bortezomib

• CAS Number :

  179324-69-7

• Synonyms :

  LDP-341, MLM341, NSC 681239, PS-341, BTZ

• SKU :

  C07434-1g

• Target :

  Proteasome

• Applications :

  Proteases

• Smiles :

  B (C (CC (C) C) NC (=O) C (CC1=CC=CC=C1) NC (=O) C2=NC=CN=C2) (O) O

• Molecular Formula :

  C19H25BN4O4

• Additionnal Information :

  Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.

• Storage Conditions :

  3 years -20°C (in the dark) powder1 year -80°C (in the dark) in solvent