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Linifanib (ABT-869)

CAT: 1568-C07424-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:1568-C07424-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
796967-16-3
Synonyms
AL39324, RG3635
SKU
C07424-5mg
Target
CSF-1R
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC (=C (C=C1) F) NC (=O) NC2=CC=C (C=C2) C3=C4C (=CC=C3) NN=C4N
Molecular Formula
C21H18FN5O
Additionnal Information
Linifanib (ABT-869, AL39324, RG3635) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively, mostly effective in mutant kinase-dependent cancer cells (i.e. FLT3) . Linifanib (ABT-869) induces autophagy and apoptosis. Phase 3.
Storage Conditions
2 years -80 in solvent

Chemical Information

Linifanib

Linifanib is a member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 2-fluoro-5-methylphenyl group, while the other is substituted by a p-(3-amino-1H-indazol-4-yl)phenyl group. It is a potent, selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases. It has a role as an antineoplastic agent, an angiogenesis inhibitor and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a member of phenylureas, an aromatic amine and a member of indazoles.

CAS Number796967-16-3
PubChem CID11485656
IUPAC Name1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
Molecular FormulaC21H18FN5O
Molecular Weight375.4
XLogP3.9
Topological Polar Surface Area95.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity541
SMILES
CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N
InChI
InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
InChIKey
MPVGZUGXCQEXTM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Linifanib
CAS: 796967-16-3
CID: 11485656
Formula: C21H18FN5O
MW: 375.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight375.4
XLogP33.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass375.14953838
Monoisotopic Mass375.14953838
Topological Polar Surface Area95.8 Ų
Heavy Atom Count28
Formal Charge0
Complexity541
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
A2949-25Linifanib (ABT-869)
A10025-200Linifanib (ABT-869) 200mg
A10025-100Linifanib (ABT-869) 100mg
A10025-5Linifanib (ABT-869) 5mg
A10025-500Linifanib (ABT-869) 500mg
A10025-50Linifanib (ABT-869) 50mg
A10025-25Linifanib (ABT-869) 25mg
A10025-10Linifanib (ABT-869) 10mg
A10025-10mM-DLinifanib (ABT-869) 10mM * 1mL in DMSO
sc-359037AABT-869

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