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ABT-737

CAT: 1568-C07423-01Size: 5 mgDry Ice: YesHazardous: No
CAT#:1568-C07423-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
852808-04-9
SKU
C07423-5mg
Target
Bcl-2
Applications
Apoptosis
Smiles
CN (C) CCC (CSC1=CC=CC=C1) NC2=C (C=C (C=C2) S (=O) (=O) NC (=O) C3=CC=C (C=C3) N4CCN (CC4) CC5=CC=CC=C5C6=CC=C (C=C6) Cl) [N+] (=O) [O-]
Molecular Formula
C42H45ClN6O5S2
Additionnal Information
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.
Storage Conditions
2 years -80 in solvent

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Alternative Products

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abx082597-01ABT-737
MBS6030015-01ABT 737

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