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Varoglutamstat

CAT: 1568-C07325-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:1568-C07325-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1276021-65-8
Synonyms
PQ912
SKU
C07325-5mg
Target
Others
Applications
Others
Smiles
CCCOC1=CC=C (C=C1) C2CNC (=O) N2C3=CC4=C (C=C3) N=CN4
Molecular Formula
C19H20N4O2
Additionnal Information
Varoglutamstat (PQ912) is an inhibitor of glutaminyl cyclase (QC), inhibiting human glutaminyl cyclase (hQC) activity with a Ki of 25 nM (pH 8.0) . It reduces pyroglutamyl-Aβ (pE-Aβ) levels and can be used in Alzheimer's disease research.

Chemical Information

Varoglutamstat
CAS Number1276021-65-8
PubChem CID51030870
IUPAC Name(5S)-1-(3H-benzimidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one
Molecular FormulaC19H20N4O2
Molecular Weight336.4
XLogP2.8
Topological Polar Surface Area70.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity466
SMILES
CCCOC1=CC=C(C=C1)[C@H]2CNC(=O)N2C3=CC4=C(C=C3)N=CN4
InChI
InChI=1S/C19H20N4O2/c1-2-9-25-15-6-3-13(4-7-15)18-11-20-19(24)23(18)14-5-8-16-17(10-14)22-12-21-16/h3-8,10,12,18H,2,9,11H2,1H3,(H,20,24)(H,21,22)/t18-/m1/s1
InChIKey
XHIKZWOEFZENIX-GOSISDBHSA-N
Chemical Structure
2D Structure
2D structure of Varoglutamstat
CAS: 1276021-65-8
CID: 51030870
Formula: C19H20N4O2
MW: 336.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight336.4
XLogP32.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass336.15862589
Monoisotopic Mass336.15862589
Topological Polar Surface Area70.3 Ų
Heavy Atom Count25
Formal Charge0
Complexity466
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
S0792-5mgVaroglutamstat

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