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MAZ51

CAT: 1568-C07304-02Size: 10 mM / 1 mLDry Ice: NoHazardous: No
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CAT#:1568-C07304-02Size:10 mM / 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
163655-37-6
SKU
C07304-5mg
Target
VEGFR
Applications
Protein Tyrosine Kinase
Smiles
CN (C) C1=CC=C (C2=CC=CC=C21) C=C3C4=CC=CC=C4NC3=O
Molecular Formula
C21H18N2O
Additionnal Information
MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR) -3 (Flt-4) tyrosine kinase. MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3β and activation of RhoA. MAZ51 inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.
Storage Conditions
3 years -20°C powder

Chemical Information

3-(4-Dimethylaminonaphthalen-1-ylmethylene)-1,3-dihydroindol-2-one
CAS Number163655-37-6
PubChem CID24906291
IUPAC Name3-[[4-(dimethylamino)naphthalen-1-yl]methylidene]-1H-indol-2-one
Molecular FormulaC21H18N2O
Molecular Weight314.4
XLogP4.3
Topological Polar Surface Area32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity512
SMILES
CN(C)C1=CC=C(C2=CC=CC=C21)C=C3C4=CC=CC=C4NC3=O
InChI
InChI=1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)
InChIKey
VFCXONOPGCDDBQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-Dimethylaminonaphthalen-1-ylmethylene)-1,3-dihydroindol-2-one
CAS: 163655-37-6
CID: 24906291
Formula: C21H18N2O
MW: 314.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight314.4
XLogP34.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass314.141913202
Monoisotopic Mass314.141913202
Topological Polar Surface Area32.3 Ų
Heavy Atom Count24
Formal Charge0
Complexity512
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

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MBS3846854-01MAZ51
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A22331-5MAZ51 5mg
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A22331-100MAZ51 100mg

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