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SPA-10091-HCl

CAT: 1568-C04931Size: 1 mgDry Ice: NoHazardous: No
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CAT#:1568-C04931Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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SKU
C04931-1mg
Target
DOT1
Applications
Epigenetics
Additionnal Information
SPA-10091-HCl is a degrader of DOT1L that selectively degrades DOT1L protein through the nuclear ubiquitin-proteasome pathway, thereby suppressing H3K79 methylation in CRPC cells. It also inhibits DOT1L enzymatic activity with an IC50 of 0.87 μM, induces apoptosis, and significantly reduces tumor growth in vivo.

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