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Thalidomide-O-amido-C4-N3

CAT: 1568-C04566Size: 5 mgDry Ice: YesHazardous: No
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CAT#:1568-C04566Size:5 mg
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CAS Number
2098488-36-7
Synonyms
Cereblon Ligand-Linker Conjugates 4, E3 ligase Ligand-Linker Conjugates 18
SKU
C04566-5mg
Additionnal Information
Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Storage Conditions
3 years-20°C powder 2 years-80°C in solvent

Chemical Information

Thalidomide-O-amido-C4-N3
CAS Number2098488-36-7
PubChem CID131704500
IUPAC NameN-(4-azidobutyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
Molecular FormulaC19H20N6O6
Molecular Weight428.4
XLogP1.1
Topological Polar Surface Area136
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Heavy Atom Count31
Formal Charge0
Complexity810
SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCCCN=[N+]=[N-]
InChI
InChI=1S/C19H20N6O6/c20-24-22-9-2-1-8-21-15(27)10-31-13-5-3-4-11-16(13)19(30)25(18(11)29)12-6-7-14(26)23-17(12)28/h3-5,12H,1-2,6-10H2,(H,21,27)(H,23,26,28)
InChIKey
USWFAZSQVLTHHA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Thalidomide-O-amido-C4-N3
CAS: 2098488-36-7
CID: 131704500
Formula: C19H20N6O6
MW: 428.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight428.4
XLogP31.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass428.14443238
Monoisotopic Mass428.14443238
Topological Polar Surface Area136 Ų
Heavy Atom Count31
Formal Charge0
Complexity810
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BUP02126-01Thalidomide-O-amido-C4-N3
A20097-100Thalidomide-O-amido-C4-N3 100mg
A20097-50Thalidomide-O-amido-C4-N3 50mg
A20097-25Thalidomide-O-amido-C4-N3 25mg
A20097-5Thalidomide-O-amido-C4-N3 5mg
A20097-2Thalidomide-O-amido-C4-N3 2mg
A20097-1000Thalidomide-O-amido-C4-N3 1g
A20097-500Thalidomide-O-amido-C4-N3 500mg
A20097-10Thalidomide-O-amido-C4-N3 10mg
HY-W999741Thalidomide-O-C4-N3

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