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Ulixertinib hydrochloride

CAT: 1568-C04456Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C04456Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1956366-10-1
Synonyms
BVD-523 hydrochloride, VRT752271 hydrochloride
SKU
C04456-5mg
Target
ERK
Applications
MAPK
Additionnal Information
Ulixertinib hydrochloride (BVD-523 hydrochloride, VRT752271 hydrochloride) is a highly selective, ATP-competitive, and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. It also reduces A375 cell proliferation with an IC50 of 180 nM and inhibits phosphorylated ERK (pERK) and the downstream kinase RSK (pRSK) in the A375 melanoma cell line, with IC50 values of 4.1 μM and 0.14 μM, respectively.

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