Lenalidomide hemihydrate

CAT: 1568-C03678-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:1568-C03678-01Size:100 mg
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CAS Number
847871-99-2
Synonyms
CC-5013 hemihydrate
SKU
C03678-100mg
Target
TNF-alpha
Applications
Apoptosis
Additionnal Information
Lenalidomide hemihydrate (CC-5013 hemihydrate) is a potent inhibitor of TNF-alpha with a IC50 of 13 nM. It induces tyrosine phosphorylation of CD28 on T cells, which subsequently activates NF-κB. It acts as a ligand for the ubiquitin E3 ligase cereblon (CRBN), leading to the selective ubiquitination and degradation of the lymphoid transcription factors IKZF1 and IKZF3 through the CRBN-CRL4 ubiquitin ligase complex.

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