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AM-9022

CAT: 1568-C03618-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1568-C03618-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2446872-46-2
SKU
C03618-5mg
Target
Kinesin
Applications
Cytoskeletal Signaling
Additionnal Information
AM-9022 is an orally active, potent, and selective inhibitor of KIF18A, a mitotic kinesin motor protein critical for chromosome alignment and segregation. It exhibits significant anti-cancer effects in human breast and ovarian tumor models.

Chemical Information

CID 148785380
CAS Number2446872-46-2
PubChem CID148785380
IUPAC Name2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-[[(2R)-1-hydroxypropan-2-yl]sulfonylamino]benzamide
Molecular FormulaC27H36F2N6O4S
Molecular Weight578.7
XLogP4.2
Topological Polar Surface Area136
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count8
Heavy Atom Count40
Formal Charge0
Complexity989
SMILES
CC1=CC(=NC(=N1)N2CCC(CC2)(F)F)NC(=O)C3=C(C=C(C=C3)NS(=O)(=O)[C@H](C)CO)N4CCC5(CC5)CC4
InChI
InChI=1S/C27H36F2N6O4S/c1-18-15-23(32-25(30-18)35-13-9-27(28,29)10-14-35)31-24(37)21-4-3-20(33-40(38,39)19(2)17-36)16-22(21)34-11-7-26(5-6-26)8-12-34/h3-4,15-16,19,33,36H,5-14,17H2,1-2H3,(H,30,31,32,37)/t19-/m1/s1
InChIKey
OLCRYQGHHMGOJZ-LJQANCHMSA-N
Chemical Structure
2D Structure
2D structure of CID 148785380
CAS: 2446872-46-2
CID: 148785380
Formula: C27H36F2N6O4S
MW: 578.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight578.7
XLogP34.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count8
Exact Mass578.24868115
Monoisotopic Mass578.24868115
Topological Polar Surface Area136 Ų
Heavy Atom Count40
Formal Charge0
Complexity989
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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