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Olomorasib

CAT: 1568-C03604-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:1568-C03604-03Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2771246-13-8
SKU
C03604-1mg
Target
Ras
Applications
Apoptosis
Additionnal Information
Olomorasib (KRAS G12C inhibitor 19, LY3537982) is a potent and highly selective second-generation inhibitor of GDP-bound KRAS G12C, with the potential to treat patients with advanced solid tumors carrying the KRAS G12C mutation.

Chemical Information

Olomorasib

Olomorasib is a small molecule drug. The usage of the INN stem '-rasib' in the name indicates that Olomorasib is a Ras protein inhibitor. Olomorasib is under investigation in clinical trial NCT06890598 (Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer). Olomorasib has a monoisotopic molecular weight of 528.08 Da.

CAS Number2771246-13-8
PubChem CID156472638
IUPAC Name4-[(13aS)-10-chloro-8-fluoro-6-oxo-2-prop-2-enoyl-1,3,4,12,13,13a-hexahydropyrazino[2,1-d][1,5]benzoxazocin-9-yl]-2-amino-7-fluoro-1-benzothiophene-3-carbonitrile
Molecular FormulaC25H19ClF2N4O3S
Molecular Weight529.0
XLogP4.8
Topological Polar Surface Area128
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count2
Heavy Atom Count36
Formal Charge0
Complexity952
SMILES
C=CC(=O)N1CCN2[C@H](C1)CCOC3=C(C(=C(C=C3C2=O)F)C4=C5C(=C(SC5=C(C=C4)F)N)C#N)Cl
InChI
InChI=1S/C25H19ClF2N4O3S/c1-2-18(33)31-6-7-32-12(11-31)5-8-35-22-14(25(32)34)9-17(28)20(21(22)26)13-3-4-16(27)23-19(13)15(10-29)24(30)36-23/h2-4,9,12H,1,5-8,11,30H2/t12-/m0/s1
InChIKey
OZUPICRWMLEFCS-LBPRGKRZSA-N
Chemical Structure
2D Structure
2D structure of Olomorasib
CAS: 2771246-13-8
CID: 156472638
Formula: C25H19ClF2N4O3S
MW: 529.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight529.0
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count2
Exact Mass528.0834457
Monoisotopic Mass528.0834457
Topological Polar Surface Area128 Ų
Heavy Atom Count36
Formal Charge0
Complexity952
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-132980-01Olomorasib
A24221-5Olomorasib (KRAS G12C inhibitor 19) 5mg
A24221-100Olomorasib (KRAS G12C inhibitor 19) 100mg
A24221-50Olomorasib (KRAS G12C inhibitor 19) 50mg
A24221-10Olomorasib (KRAS G12C inhibitor 19) 10mg

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