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Remodelin

CAT: 1568-C03561-04Size: 1 gDry Ice: NoHazardous: No
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CAT#:1568-C03561-04Size:1 g
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CAS Number
949912-58-7
SKU
C03561-25mg
Target
Histone Acetyltransferase
Applications
Epigenetics
Additionnal Information
Remodelin is a potential inhibitor of the acetyltransferase NAT10. It enhances nuclear shape and cellular fitness in both progeric cells and cells depleted of Lamin A/C by inhibiting NAT10. Remodelin exhibits anti-proliferation activity and significantly inhibits tumour growth and tumour cell proliferation in the PDX model of HNSCC.

Chemical Information

4-(4-Cyanophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole

a NAT10 inhibitor; structure in first source

CAS Number949912-58-7
PubChem CID44442376
IUPAC Name4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
Molecular FormulaC15H14N4S
Molecular Weight282.4
XLogP3.3
Topological Polar Surface Area89.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity397
SMILES
C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1
InChI
InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19)
InChIKey
XAEJIFARBQJLML-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(4-Cyanophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole
CAS: 949912-58-7
CID: 44442376
Formula: C15H14N4S
MW: 282.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight282.4
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass282.09391764
Monoisotopic Mass282.09391764
Topological Polar Surface Area89.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity397
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B4887-5Remodelin
GTR19162959-01Remodelin hydrobromide

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