MS41

CAT: 1568-C03331-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:1568-C03331-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2768610-97-3
SKU
C03331-5mg
Target
Others
Applications
Others
Additionnal Information
MS41 is a highly potent and selective PROTAC degrader of eleven-nineteen leukemia (ENL) that recruits the von Hippel–Lindau (VHL) E3 ubiquitin ligase, with DC50 values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1) . It suppresses oncogenic gene expression, inhibits leukemia cell proliferation, and reduces MLL-r leukemia progression in a xenograft mouse model.

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