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BI605906

CAT: 1568-C02098Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C02098Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
960293-88-3
SKU
C02098-5mg
Target
IκB/IKK
Applications
NF-κB
Additionnal Information
BI605906 is a selective inhibitor of IKKβ with an IC50 of 380 nM when assayed at 0.1 mM ATP, suppressing the phosphorylation and activation of IKKβ, modulating NF-κB signalling. It also inhibits the insulin-like growth factor 1 (IGF1) receptor, with an IC50 of 7.6 μM. BI605906 effectively blocks TNF-α-dependent IκB degradation and reduces the expression of proinflammatory cytokines, including IL-6, IL-1β, and C-X-C motif ligands CXCL1/2.

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