ART0380

CAT: 1568-C02002-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:1568-C02002-01Size:5 mg
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CAS Number
2267316-76-5
Synonyms
IACS-030380
SKU
C02002-5mg
Target
ATM/ATR
Applications
PI3K/Akt/mTOR
Additionnal Information
ART0380 (IACS-030380) is a potent and selective, orally bioavailable inhibitor of ATR kinase, with an IC50 of 51.7 nM effectively inhibiting the enzyme activity of the ATR-ATRIP complex. It functions as an ATP-competitive inhibitor, binding to the ATP pocket of ATR, where ATP would typically bind. It interacts with the hinge through its morpholine oxygen and occupies the ribose pocket with a sulfoximine group. It also exhibits antitumor activity.

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BA3712-1ART0380
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HY-157941A-01(R, R) -ART0380

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