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HC-7366

CAT: 1568-C01992-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C01992-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2803470-63-3
SKU
C01992-5mg
Target
Serine/threonin kinase
Applications
Cell Cycle
Additionnal Information
HC-7366, is a First-in-Human modulator of General controlled nonderepressible 2 (GCN2) that activates GCN2. It demonstrates anti-metastatic efficacy, reducing lung metastases and exhibits anti-tumor activity.

Chemical Information

Hibercell GCN2 inhibitor HC-7366

GCN2 Activator HC-7366 is an activator of the serine/threonine protein kinase general control nonderepressible 2 (GCN2), with potential antineoplastic and immunomodulating activities. Upon administration, GCN2 activator HC-7366 targets and binds to, and activates GCN2, which phosphorylates eukaryotic translation initiation factor 2A (eIF2A), thereby inducing cyclic AMP-dependent transcription factor ATF-4 transcription and ATF-4-mediated integrated stress response (ISR). This may result in apoptosis. GCN2 plays a key role in the activation of the ISR pathway in response to amino acid deprivation and in hypoxic tumors. While ISR promotes the adaptation of tumor cells to hypoxic stress, prolonged activation of ISR induces apoptosis.

CAS Number2803470-63-3
PubChem CID164593978
IUPAC Name6-[3-[(5-chloro-2-methoxy-3-pyridinyl)sulfonylamino]-2,6-difluorophenyl]-N-methylimidazo[1,5-a]pyrazine-1-carboxamide
Molecular FormulaC20H15ClF2N6O4S
Molecular Weight508.9
XLogP2.6
Topological Polar Surface Area136
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity838
SMILES
CNC(=O)C1=C2C=NC(=CN2C=N1)C3=C(C=CC(=C3F)NS(=O)(=O)C4=C(N=CC(=C4)Cl)OC)F
InChI
InChI=1S/C20H15ClF2N6O4S/c1-24-19(30)18-14-7-25-13(8-29(14)9-27-18)16-11(22)3-4-12(17(16)23)28-34(31,32)15-5-10(21)6-26-20(15)33-2/h3-9,28H,1-2H3,(H,24,30)
InChIKey
KIGXQRBUVDDSPP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hibercell GCN2 inhibitor HC-7366
CAS: 2803470-63-3
CID: 164593978
Formula: C20H15ClF2N6O4S
MW: 508.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight508.9
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Exact Mass508.0532082
Monoisotopic Mass508.0532082
Topological Polar Surface Area136 Ų
Heavy Atom Count34
Formal Charge0
Complexity838
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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