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PCO371

CAT: 1568-C01931-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C01931-01Size:5 mg
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CAS Number
1613373-33-3
SKU
C01931-5mg
Target
Others
Applications
Others
Additionnal Information
PCO371 is a nonpeptidyl, orally active agonist of Parathyroid hormone type 1 receptor (PTHR1) . It stimulates cAMP production in COS-7 cells with an EC50 of 2.4 μmol/L. It also acts as an osteoporosis drug and significantly enhances bone mineral density (BMD) and bone strength in the lumbar vertebrae of osteopenic ovariectomized (OVX) rats. It also restores normal serum calcium levels without increasing urinary calcium in hypocalcemic thyroparathyroidectomized (TPTX) rats.

Chemical Information

Pco-371

PCO-371 is under investigation in clinical trial NCT02475616 (A Single Ascending Dose Study of PCO371 in Healthy Volunteers).

CAS Number1613373-33-3
PubChem CID76283707
IUPAC Name1-[3,5-dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethylimidazolidine-2,4-dione
Molecular FormulaC29H32F3N5O6S
Molecular Weight635.7
XLogP3.7
Topological Polar Surface Area146
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Heavy Atom Count44
Formal Charge0
Complexity1270
SMILES
CC1=CC(=CC(=C1CCS(=O)(=O)N2CCC3(CC2)C(=O)NC(=N3)C4=CC=C(C=C4)OC(F)(F)F)C)N5C(=O)NC(=O)C5(C)C
InChI
InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44(41,42)36-12-10-28(11-13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30,31)32/h5-8,15-16H,9-14H2,1-4H3,(H,33,35,39)(H,34,38,40)
InChIKey
LDZJFVOUPUFOHX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pco-371
CAS: 1613373-33-3
CID: 76283707
Formula: C29H32F3N5O6S
MW: 635.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight635.7
XLogP33.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Exact Mass635.20253942
Monoisotopic Mass635.20253942
Topological Polar Surface Area146 Ų
Heavy Atom Count44
Formal Charge0
Complexity1270
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA9262-5PCO371
A20493-10PCO371 10mg
HY-100856RPCO371 (Standard)
A20493-5PCO371 5mg
A20493-25PCO371 25mg
A20493-1PCO371 1mg
A20493-100PCO371 100mg
A20493-50PCO371 50mg
A20493-10mM-DPCO371 10mM * 1mL in DMSO

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