PF-06952229

• CAS Number :

  1801333-55-0

• Synonyms :

  UNII-1KKS7U3X86

• SKU :

  C01872-5mg

• Target :

  TGF-beta/Smad

• Applications :

  TGF-beta/Smad

• Additionnal Information :

  PF-06952229 (UNII-1KKS7U3X86) is a selective, orally available inhibitor of the serine/threonine kinase TGF-β receptor 1 (TGF-β-R1) . It inhibits pSMAD2 in both tumor and immune cells, reducing TGF-β signalling and reversing EMT in vitro. It modulates the tumor immune microenvironment and shows antitumor activity in mouse models.

• Storage Conditions :

  2 years -20°C liquid