SR9011

CAT: 1568-C01822-02Size: 25 mgDry Ice: NoHazardous: No

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CAT#:1568-C01822-02Size:25 mg

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CAS Number

1379686-29-9

SKU

C01822-5mg

Target

Others

Applications

Others

Additionnal Information

SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. It is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi.

Chemical Information

3-((((4-Chlorophenyl)methyl)((5-nitro-2-thienyl)methyl)amino)methyl)-N-pentyl-1-pyrrolidinecarboxamide

SR-9011 is a REV-ERB agonist. SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues.

CAS Number	1379686-29-9
PubChem CID	57394021
IUPAC Name	3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]-N-pentylpyrrolidine-1-carboxamide
Molecular Formula	C23H31ClN4O3S
Molecular Weight	479.0
XLogP	5.3
Topological Polar Surface Area	110
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	10
Heavy Atom Count	32
Formal Charge	0
Complexity	600

SMILES

CCCCCNC(=O)N1CCC(C1)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-]

InChI

InChI=1S/C23H31ClN4O3S/c1-2-3-4-12-25-23(29)27-13-11-19(16-27)15-26(14-18-5-7-20(24)8-6-18)17-21-9-10-22(32-21)28(30)31/h5-10,19H,2-4,11-17H2,1H3,(H,25,29)

InChIKey

PPUYOYQTTWJTIU-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1379686-29-9

CID: 57394021

Formula: C23H31ClN4O3S

MW: 479.0

Interactive 3D Structure

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Computed Properties

Property	Value
Molecular Weight	479.0
XLogP3	5.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	10
Exact Mass	478.1805397
Monoisotopic Mass	478.1805397
Topological Polar Surface Area	110 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	600
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
EFC68629-01	SR9011
VHD01494-01	Sr9011 hydrochloride
A20892-2	SR9011 2mg
HY-16988A-01	SR9011 (hydrochloride)
A20892-100	SR9011 100mg
A20892-1	SR9011 1mg

SR9011

Chemical Information

Alternative Products

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