KT 474

• CAS Number :

  2432994-31-3

• Synonyms :

  SAR-444656

• SKU :

  C01784-1mg

• Target :

  IRAK

• Applications :

  Immunology & Inflammation

• Additionnal Information :

  KT-474 (SAR444656) is a selective small-molecule degrader of IRAK4 in development for the treatment of TLR/IL-1R–driven autoimmune diseases. KT-474 potently downregulates R848 (TLR7/8) and lipopolysaccharide (LPS) -induced IL-6 and IL-8 production in peripheral blood mononuclear cells (PBMCs) .