Exarafenib

CAT: 1568-C01780-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:1568-C01780-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2639957-39-2
Synonyms
KIN-002787, KIN-2787, RAF/KIN_2787
SKU
C01780-5mg
Target
Raf
Applications
MAPK
Additionnal Information
Exarafenib (KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. KIN-2787 exhibits low nanomolar to picomolar potency against RAF1, BRAF, and ARAF with an IC50 of 0.06-3.46 nM with minimal activity towards non-RAF kinases.

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