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IK-930

CAT: 1568-C01698-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C01698-01Size:5 mg
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CAS Number
2563892-44-2
SKU
C01698-5mg
Target
TEAD
Applications
Hippo
Additionnal Information
IK-930 is a selective, small-molecule inhibitor of TEAD that prevents palmitate binding and thereby disrupts aberrant TEAD-dependent transcription. IK-930 demonstrates antitumor activity in mouse xenograft models with Hippo pathway genetic alterations.

Chemical Information

N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-(((4-(trifluoromethyl)phenyl)methyl)amino)benzene-1-sulfonamide

IK-930 is an oral, paralog-selective TEAD inhibitor.

CAS Number2563892-44-2
PubChem CID155342988
IUPAC NameN-methyl-3-(1-methylimidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]methylamino]benzenesulfonamide
Molecular FormulaC19H19F3N4O2S
Molecular Weight424.4
XLogP3
Topological Polar Surface Area84.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity632
SMILES
CNS(=O)(=O)C1=CC(=C(C=C1)NCC2=CC=C(C=C2)C(F)(F)F)C3=CN(C=N3)C
InChI
InChI=1S/C19H19F3N4O2S/c1-23-29(27,28)15-7-8-17(16(9-15)18-11-26(2)12-25-18)24-10-13-3-5-14(6-4-13)19(20,21)22/h3-9,11-12,23-24H,10H2,1-2H3
InChIKey
TVBGCXJDLVRDSU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-(((4-(trifluoromethyl)phenyl)methyl)amino)benzene-1-sulfonamide
CAS: 2563892-44-2
CID: 155342988
Formula: C19H19F3N4O2S
MW: 424.4
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight424.4
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass424.11808152
Monoisotopic Mass424.11808152
Topological Polar Surface Area84.4 Ų
Heavy Atom Count29
Formal Charge0
Complexity632
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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