HS-276

• CAS Number :

  2767422-72-8

• SKU :

  C01511-5mg

• Target :

  TAK1

• Applications :

  MAPK

• Smiles :

  CCC[N]1C (=NC2=CC=C (CN3CCCCC3) C=C12) NC (=O) C4=CC=CC (=C4) C (N) =O

• Additionnal Information :

  HS-276, a potent and highly selective orally bioavailable transforming growth factor-β activated kinase-1 (TAK1) inhibitor with the Ki and IC50 of 2.5 nM and 2.3 nM respectively, shows significant inhibition of TNF-mediated cytokine profiles, correlating with significant attenuation of arthritic-like symptoms in the collagen-induced arthritis (CIA) mouse model of inflammatory rheumatoid arthritis (RA) .

• Storage Conditions :

  3 years -20°C powder