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GW280264X

CAT: 1568-C01426Size: 1 mgDry Ice: NoHazardous: No
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CAT#:1568-C01426Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
866924-39-2
SKU
C01426-1mg
Additionnal Information
GW280264X is a potent hydroxamate inhibitor of mixed ADAM10/TACE (ADAM17) . It potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively. It inhibits constitutive and PMA-inducible CX3CL1 shedding and increases adhesive properties in CX3CL1 transfected cells. Its treatment significantly improves functional recovery after spinal cord injury.

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