Pimonidazole

• UNSPSC Description:

  Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pimonidazole.html

• Purity:

  99.07

• Solubility:

  H2O : 1 mg/mL (ultrasonic)

• Smiles:

  OC(CN1C=CN=C1[N+]([O-])=O)CN2CCCCC2

• Molecular Weight:

  254.29

• References & Citations:

  [1]Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7.|[2]Masaki Y, et al. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016 Aug 31;11(8):e0161639.Sci Rep. 2023 Apr 21;13(1):6528.|Theranostics. 2022 Apr 4;12(7):3196-3216.|Asian J Pharm Sci. 2023 Mar 20.|J Colloid Interface Sci. 2024 May:661:908-922.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  Phase 2

• CAS Number:

  70132-50-2