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JNJ-38877618 2mg

CAT: 0628-A18325-2Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0628-A18325-2Size:2 mg
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CAS Number
943540-74-7

Chemical Information

6-[Difluoro-(6-pyridin-4-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]quinoline

MET Kinase Inhibitor OMO-1 is an inhibitor of the proto-oncogene and receptor tyrosine kinase (RTK) hepatocyte growth factor receptor (c-Met; HGFR; MET) with potential antineoplastic activity. Upon administration, OMO-1 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.

CAS Number943540-74-7
PubChem CID57654476
IUPAC Name6-[difluoro-(6-pyridin-4-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]quinoline
Molecular FormulaC20H12F2N6
Molecular Weight374.3
XLogP2.7
Topological Polar Surface Area68.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity543
SMILES
C1=CC2=C(C=CC(=C2)C(C3=NN=C4N3N=C(C=C4)C5=CC=NC=C5)(F)F)N=C1
InChI
InChI=1S/C20H12F2N6/c21-20(22,15-3-4-16-14(12-15)2-1-9-24-16)19-26-25-18-6-5-17(27-28(18)19)13-7-10-23-11-8-13/h1-12H
InChIKey
KOAWAWHSMVKCON-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-[Difluoro-(6-pyridin-4-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]quinoline
CAS: 943540-74-7
CID: 57654476
Formula: C20H12F2N6
MW: 374.3
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight374.3
XLogP32.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass374.10915073
Monoisotopic Mass374.10915073
Topological Polar Surface Area68.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity543
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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T15617-01JNJ-38877618
TMB54074-01JNJ-38877618 (OMO-1)
MBS131356JNJ-63533054 (JNJ63533054; JNJ 63533054)
MBS3603460-01JNJ-55308942
FPD27376-01JNJ-67856633
WRB44790-01JNJ 39758979
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