C24-Ceramide

• Description:

  C24-Ceramide is an orally active competitive binding agonist of PIP4K2C (mTOR complex regulator), thereby activating the mTOR signaling pathway. At the same time, C24-Ceramide changes the membrane morphology by inducing the formation of a partially interlocked gel phase in the phospholipid bilayer. C24-Ceramide can promote the proliferation and migration of keratinocytes to accelerate skin wound healing and drive the proliferation and metastasis of gallbladder cancer cells. The level of C24-Ceramide in serum can be used as a diagnostic marker for gallbladder cancer[1][2][3].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  MTOR

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/c24-ceramide.html

• Purity:

  99.92

• Solubility:

  DMSO : < 1 mg/mL (ultrasonic; warming) |Ethanol : 25 mg/mL (ultrasonic) |THF : 25 mg/mL (ultrasonic)

• Smiles:

  CCCCCCCCCCCCCCCCCCCCCCCC (N[C@@H] (CO) [C@H] (O) /C=C/CCCCCCCCCCCCC) =O

• Molecular Formula:

  C42H83NO3

• Molecular Weight:

  650.11

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Ventura AE, et al. Lipid domain formation and membrane shaping by C24-ceramide. Biochim Biophys Acta Biomembr. 2020 Oct 1;1862 (10) :183400.|[2]Lee JH, et al. C24 Ceramide Lipid Nanoparticles for Skin Wound Healing. Pharmaceutics. 2025 Feb 12;17 (2) :242.|[3]Zhang Y, et al. C24-Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation. Hepatology. 2021 Feb;73 (2) :692-712.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  34435-05-7