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C24-Ceramide

CAT: 0804-HY-134508-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134508-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C24-Ceramide is an orally active competitive binding agonist of PIP4K2C (mTOR complex regulator), thereby activating the mTOR signaling pathway. At the same time, C24-Ceramide changes the membrane morphology by inducing the formation of a partially interlocked gel phase in the phospholipid bilayer. C24-Ceramide can promote the proliferation and migration of keratinocytes to accelerate skin wound healing and drive the proliferation and metastasis of gallbladder cancer cells. The level of C24-Ceramide in serum can be used as a diagnostic marker for gallbladder cancer[1][2][3].
CAS Number
34435-05-7
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c24-ceramide.html
Purity
99.92
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming) |Ethanol : 25 mg/mL (ultrasonic) |THF : 25 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
Molecular Formula
C42H83NO3
Molecular Weight
650.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Ventura AE, et al. Lipid domain formation and membrane shaping by C24-ceramide. Biochim Biophys Acta Biomembr. 2020 Oct 1;1862 (10) :183400.|[2]Lee JH, et al. C24 Ceramide Lipid Nanoparticles for Skin Wound Healing. Pharmaceutics. 2025 Feb 12;17 (2) :242.|[3]Zhang Y, et al. C24-Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation. Hepatology. 2021 Feb;73 (2) :692-712.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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