Products for Research Use Only
RegisterLogin

E-7386 10mM * 1mL in DMSO

CAT: 0628-A17089-10mM-DSize: 10 mM x 1mL in DMSODry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0628-A17089-10mM-DSize:10 mM x 1mL in DMSO
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1799824-08-0

Chemical Information

E-7386

CBP/beta-catenin Modulator E7386 is an orally bioavailable, specific inhibitor of the canonical Wnt/beta-catenin signaling pathway, with potential antineoplastic activity. Upon oral administration, CBP/beta-catenin modulator E7386 inhibits beta-catenin and prevents the interaction of beta-catenin with its transcriptional coactivator, CREB (cAMP response element-binding) binding protein (CBP). This prevents binding of beta-catenin/CBP to WRE (Wnt-responsive element), and inhibits the activation of transcription of a wide range of target genes of Wnt/beta-catenin signaling, thereby preventing gene expression of many Wnt-related, pro-survival proteins and suppressing tumor cell growth. The Wnt/beta-catenin signaling pathway regulates cell morphology, motility, and proliferation; aberrant regulation of this pathway leads to neoplastic proliferation. Beta-catenin is frequently mutated in various tumors.

CAS Number1799824-08-0
PubChem CID91810345
IUPAC Name(6S,9aS)-N-benzyl-8-[[6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]-2-pyridinyl]methyl]-6-[(2-fluoro-4-hydroxyphenyl)methyl]-4,7-dioxo-2-prop-2-enyl-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazine-1-carboxamide
Molecular FormulaC39H48FN9O4
Molecular Weight725.9
XLogP3.4
Topological Polar Surface Area119
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Heavy Atom Count53
Formal Charge0
Complexity1280
SMILES
CCN1CCN(CC1)C2CN(C2)C3=CC=CC(=N3)CN4C[C@H]5N([C@H](C4=O)CC6=C(C=C(C=C6)O)F)C(=O)CN(N5C(=O)NCC7=CC=CC=C7)CC=C
InChI
InChI=1S/C39H48FN9O4/c1-3-15-47-27-37(51)48-34(20-29-13-14-32(50)21-33(29)40)38(52)46(26-36(48)49(47)39(53)41-22-28-9-6-5-7-10-28)23-30-11-8-12-35(42-30)45-24-31(25-45)44-18-16-43(4-2)17-19-44/h3,5-14,21,31,34,36,50H,1,4,15-20,22-27H2,2H3,(H,41,53)/t34-,36-/m0/s1
InChIKey
ZGNKNLOBYFTGRG-GIWKVKTRSA-N
Chemical Structure
2D Structure
2D structure of E-7386
CAS: 1799824-08-0
CID: 91810345
Formula: C39H48FN9O4
MW: 725.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight725.9
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Exact Mass725.38132921
Monoisotopic Mass725.38132921
Topological Polar Surface Area119 Ų
Heavy Atom Count53
Formal Charge0
Complexity1280
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
A15073-10mM-DE-3810 10mM * 1mL in DMSO
A13257-10mM-DE-64 10mM * 1mL in DMSO
A11393-10mM-DE 2012 10mM * 1mL in DMSO
A12042-10mM-DEleutheroside E 10mM * 1mL in DMSO
A14666-10mM-DCucurbitacin E 10mM * 1mL in DMSO
A13259-10mM-DE 64d 10mM * 1mL in DMSO
A11396-10mM-DE-7050 (Golvatinib) 10mM * 1mL in DMSO
A12504-10mM-DS1RA (E-52862) 10mM * 1mL in DMSO
A18381-10mM-D(E) -Ferulic acid 10mM * 1mL in DMSO
A16378-10mM-DTC-E 5003 10mM * 1mL in DMSO

Alternative Products

CatalogName
MD-0025-2MGY27632 (10mM in DMSO)
BUP19121Tetrahydrozoline Hydrochloride, 10mM (in DMSO)
BUP19033Tetradecyltrimethylammonium bromide, 10mM (in DMSO)
BUP19963(2S,3R,4S,5R) -2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride, 10mM (in DMSO)
BA4666-1E-7386
FE167967-01E 7386
TG308475UQCRFS1 Human shRNA Plasmid Kit (Locus ID 7386)
40470004-3DMSO

Popular Products