Products for Research Use Only
RegisterLogin

LDN-212854 1mg

CAT: 0628-A12821-1Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0628-A12821-1Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1432597-26-6

Chemical Information

Ldn-212854

LDN-212854 is a member of the class of quinolines that is quinoline substituted by a 6-[4-(piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl group at position 5. It is a potent ALK inhibitor (IC50 values of 2.4, 1.3, 85.8, 2,133 and 9,276 nM for ALK1, ALK2, ALK3, ALK4 and ALK5, respectively). It has a role as an EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor, an antineoplastic agent and an angiogenesis inhibitor. It is a member of quinolines, a pyrazolopyrimidine and a N-arylpiperazine.

CAS Number1432597-26-6
PubChem CID60182388
IUPAC Name5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Molecular FormulaC25H22N6
Molecular Weight406.5
XLogP3.3
Topological Polar Surface Area58.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count31
Formal Charge0
Complexity587
SMILES
C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=C6C=CC=NC6=CC=C5)N=C3
InChI
InChI=1S/C25H22N6/c1-3-21(22-4-2-10-27-24(22)5-1)23-16-29-31-17-19(15-28-25(23)31)18-6-8-20(9-7-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
InChIKey
BBDGBGOVJPEFBT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ldn-212854
CAS: 1432597-26-6
CID: 60182388
Formula: C25H22N6
MW: 406.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight406.5
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass406.19059473
Monoisotopic Mass406.19059473
Topological Polar Surface Area58.4 Ų
Heavy Atom Count31
Formal Charge0
Complexity587
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
A12821-25LDN-212854 25mg
A12821-100LDN-212854 100mg
A12821-50LDN-212854 50mg
A12821-10LDN-212854 10mg
A12821-5LDN-212854 5mg
A12821-10mM-DLDN-212854 10mM * 1mL in DMSO
A20415-1LDN-0088050 1mg
A20844-1LDN-27219 1mg
A21546-1LDN-192960 1mg
A20415-100LDN-0088050 100mg

Alternative Products

CatalogName
B3687-50LDN-212854
JJD41480-01Ldn 212854 trihydrochloride
B5805-10LDN 212320

Popular Products