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CFMMC

CAT: 0804-HY-116723Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116723Size:1 Each
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Description
CFMMC is a selective allosteric metabotropic glutamate receptor 1 (mGluR1) antagonist. CFMMC inhibits L-glutamate-induced intracellular Ca2+ mobilization ([Ca2+]i) in Chinese hamster ovary cells expressing recombinant human mGluR1a with an IC50 value of 50 nM. CFMMC is promising for research of various central nervous system disorders, such as schizophrenia, epilepsy, anxiety, pain, cognitive dysfunction and drug abuse[1].
CAS Number
1190598-60-7
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cfmmc.html
Smiles
O=C1C2=C(OC=C1C3CCCCC3)C=C(OCCN4CCOCC4)C(C)=C2F
Molecular Formula
C22H28FNO4
Molecular Weight
389.46
References & Citations
[1]Fukuda J, et al. Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7- (2-morpholin-4-ylethoxy) -4H-chromen-4-one. Neuropharmacology. 2009 Sep;57 (4) :438-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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