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TIMP1 Mouse mAb IHC Kit

CAT: 0808-KV0148-01Size: 3 mLDry Ice: NoHazardous: No
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CAT#:0808-KV0148-01Size:3 mL
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Background
TIMP-1 is a 28 kDa glycoprotein that functions as an inhibitor of matrix metalloproteinases (MMPs), which are key enzymes responsible for degrading major structural proteins of the extracellular matrix (ECM) . Both MMPs and TIMPs play crucial roles in ECM degradation and are involved in tumor invasion and metastasis, serving as major regulatory proteins of malignant tumor progression. TIMP-1 is upregulated in various cancers, including liver cancer, breast cancer, and colorectal cancer, and can serve as a potential biomarker for tumor progression and prognosis.
Synonyms
Metalloproteinase inhibitor 1, Erythroid-potentiating activity (EPA), Fibroblast collagenase inhibitor (Collagenase inhibitor), Tissue inhibitor of metalloproteinases 1 (TIMP-1), TIMP1, CLGI, TIMP
Gene Name
TIMP1
Gene ID
7076
Swiss Prot
P01033
Reactivity
Human
Immunogen
A synthetic peptide corresponding to the amino acid region 50 - 150 of the human TIMP1 protein.
Applications
Immunohistochemistry (IHC)
Dilution
It has been optimized for direct use, requiring no further dilution.
Specificity
The antibody can specifically recognize human TIMP1 protein.
Formulation
The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05% Proclin 300.
Subcellular Location
Cytoplasmic
Protein Name
TIMP1

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