Products for Research Use Only
RegisterLogin

PMS2 (AB1648) Rabbit mAb

CAT: 0808-M3018-01Size: 20 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0808-M3018-01Size:20 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA (X) 2E (X) 4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC, also known as Lynch syndrome) and Turcot syndrome
Synonyms
Mismatch repair endonuclease PMS2 (EC 3. 1.-.-, DNA mismatch repair protein PMS2, PMS1 protein homolog 2)
Gene Name
PMS2 PMSL2
Gene ID
5395
Swiss Prot
P54278
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein (or fragment) . This information is considered to be commercially sensitive.
Clonality
Monoclonal
Source
Monoclonal, Rabbit, IgG
Applications
WB, IHC, IF, IP, ELISA
Purification
The antibody was purified by protein A affinity chromatography.
Dilution
WB, 1:500-1:5000 | IHC, 1:200-1:1000 | IF, 1:200-1:1000 | IP, 0. 5μg-4μg antibody for 200μg-400μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Modification
Unmodified
Storage Conditions
Store at-20°C. Avoid freeze / thaw cycles.
Specificity
This antibody detects endogenous levels of PMS2 protein.
Formulation
The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.05% Proclin 300.
Protein Name
PMS2

Related Products

CatalogName
YM8020-01PMS2 (PT0045R) PT® Rabbit mAb
YM8471-01PMS2 (PT0045R) PT® Rabbit mAb
M3004-01CD8 a (AB1643) Rabbit mAb
M3060-01SOD1 (AB1698) Rabbit mAb
M3504-01UBA52 (AB1608) Rabbit mAb
M3010-01β-actin (AB1642) Rabbit mAb
M3009-01P53 (AB1641) Rabbit mAb
M3099-01UQCRC2 (AB1748) Rabbit mAb
M3047-01CD19 (AB1678) Rabbit mAb
M3179-01Adiponectin (AB1848) Rabbit mAb

Alternative Products

CatalogName
NBP3-23590-20ugRabbit Monoclonal PMS2 Antibody (PMS2/8224R)
NBP3-07615-100ugRabbit Monoclonal PMS2 Antibody (PMS2/4373R)
NBP3-20297-20ugRabbit Monoclonal PMS2 Antibody (PMS2/8374R)
RDSA66520PMS2 Rabbit mAb
GTR18603417-01PMS2 Rabbit pAb
NBP3-24032PERabbit Monoclonal PMS2 Antibody (PMS2/8224R) [PE]

Popular Products