Fipronil

CAT: 0804-HY-B0822-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0822-01Size:25 mg
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Description
Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC50s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes[1][2].
CAS Number
[120068-37-3]
UNSPSC
12352005
Hazard Statement
H301+H311+H331, H372
Target
Apoptosis; Cytochrome P450; GABA Receptor
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fipronil.html
Purity
99.49
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
N#CC1=NN(C2=C(Cl)C=C(C(F)(F)F)C=C2Cl)C(N)=C1S(C(F)(F)F)=O
Molecular Formula
C12H4Cl2F6N4OS
Molecular Weight
437.15
Precautions
H301+H311+H331, H372
References & Citations
[1]Das PC, et al. Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes. Chem Biol Interact. 2006 Dec 15;164 (3) :200-14. |[2]Narahashi T, et al. Glutamate-activated chloride channels: Unique fipronil targets present in insects but not in mammals. Pestic Biochem Physiol. 2010 Jun 1;97 (2) :149-152.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CYP1; CYP2; CYP3

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