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Flobufen

CAT: 0804-HY-106835-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106835-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Flobufen (VUFB 16066) is a non-steroidal anti-inflammatory agent and cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor agent. Flobufen inhibits alloantigen-driven cellular immune responses and stimulates phagocytosis of peritoneal cells. Flobufen can improve immunopathological disorders and has an inhibitory effect on rheumatoid arthritis[1][2][3].
CAS Number
112344-52-2
Product Name Alternative
VUFB 16066
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/flobufen.html
Purity
98.85
Solubility
DMSO : 40 mg/mL (ultrasonic;adjust pH to 9 with 1 M NaOH)
Smiles
FC1=C(C2=CC=C(C(CC(C)C(O)=O)=O)C=C2)C=CC(F)=C1
Molecular Formula
C17H14F2O3
Molecular Weight
304.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Kvasnicková E, et al. Metabolic pathways of flobufen-a new antirheumatic and antiarthritic drug. Interspecies comparison. Exp Toxicol Pathol. 1999 Jul;51 (4-5) :352-6.|[2]Drsata J, et al. Inhibice dekarboxylázy aromatických aminokyselin protizánĕtlivými látkami flobufenem a kyselinou 2',4'-difluorbifenyl-4-yloctovou [Inhibition of aromatic amino acid decarboxylases by the anti-inflammatory agent flobufen and 2',4'-difluorbiphenyl-4-acetic acid]. Cesk Farm. 1989 Nov;38 (9) :407-10.|[3]Panajotova V, et al. Pharmacological profile of the novel potent antirheumatic 4- (2',4'-difluorobiphenyl-4-yl) -2-methyl-4-oxobutanoic acid. Arzneimittelforschung.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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