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Dimethoxycurcumin

CAT: 0804-HY-100977-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100977-04Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities[1][2].
CAS Number
160096-59-3
Product Name Alternative
DiMC; CHC 004; Di-O-methylcurcumin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NF-κB; NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dimethoxycurcumin.html
Concentration
10mM
Purity
98.89
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CC(/C=C/C1=CC=C(OC)C(OC)=C1)=O)/C=C/C2=CC=C(OC)C(OC)=C2
Molecular Formula
C23H24O6
Molecular Weight
396.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Patwardhan RS, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol|[2]Pae HO, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52 (9) :1082-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Dimethoxycurcumin

has antineoplsatic activity; structure in first source

CAS Number160096-59-3
PubChem CID9952605
IUPAC Name(1E,6E)-1,7-bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione
Molecular FormulaC23H24O6
Molecular Weight396.4
XLogP3.9
Topological Polar Surface Area71.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Heavy Atom Count29
Formal Charge0
Complexity534
SMILES
COC1=C(C=C(C=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)OC)OC)OC
InChI
InChI=1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-14H,15H2,1-4H3/b9-5+,10-6+
InChIKey
HMJSBVCDPKODEX-NXZHAISVSA-N
Chemical Structure
2D Structure
2D structure of Dimethoxycurcumin
CAS: 160096-59-3
CID: 9952605
Formula: C23H24O6
MW: 396.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight396.4
XLogP33.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Exact Mass396.15728848
Monoisotopic Mass396.15728848
Topological Polar Surface Area71.1 Ų
Heavy Atom Count29
Formal Charge0
Complexity534
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5772169DimethoxyCurcumin
A15804-100Dimethoxycurcumin 100mg
A15804-25Dimethoxycurcumin 25mg
A15804-50Dimethoxycurcumin 50mg
A15804-200Dimethoxycurcumin 200mg
A15804-10Dimethoxycurcumin 10mg
A15804-5Dimethoxycurcumin 5mg
A15804-10mM-DDimethoxycurcumin 10mM * 1mL in DMSO

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