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MGH-CP1

CAT: 0804-HY-139330-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139330-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC50s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion[1].
CAS Number
896657-58-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mgh-cp1.html
Concentration
10mM
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CSC1=NN=CN1)NC2=CC=C(C=C2)C3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3
Molecular Formula
C20H24N4OS
Molecular Weight
368.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Li Q, Sun Y, Jarugumilli GK, et al. Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. Cell Stem Cell. 2020;26 (5) :675-692.e8. doi:10.1016/j.stem.2020.03.002
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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