BJJF078

CAT: 0804-HY-145933-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-145933-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

BJJF078 is an aminopiperidine derivative. BJJF078 is a potent inhibitor of recombinant human and mouse Transglutaminase enzyme (TG2) activity, IC50 values of 41 and 54 nM, respectively. BJJF078 also inhibits the close related enzyme TG1, with an IC50 of 0.16 μM. BJJF078 can be used for Multiple sclerosis (MS) research[1].

CAS Number

2531244-56-9

UNSPSC

12352005

Target

Glutaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bjjf078.html

Purity

99.34

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NC1CCN(S(=O)(C2=C3C=CC=C(NC(C4=CC=C(C(OC)=C4)OC)=O)C3=CC=C2)=O)CC1)C=C

Molecular Formula

C27H29N3O6S

Molecular Weight

523.60

References & Citations

[1]Chrobok NL, et al. Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis. PLoS One. 2018 Apr 24;13 (4) :e0196433.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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