(R)-Acenocoumarol

(R)-Acenocoumarol

• CAS Number: 66556-77-2
• UNSPSC Description: (R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) is a short-acting and orally active anticoagulant, like Warfarin (HY-B0687), works by inhibiting vitamin K epoxide reductase. (R)-Acenocoumarol has a greater in vivo anticoagulant potency than Warfarin. (R)-Acenocoumarol has a single chiral center that produces two different enantiomeric forms. (R)-Acenocoumarol has a longer plasma elimination half-life (6.6 h) and a slower plasma clearance rate (1.9 L/h) than the (S)-enantiomer, resulting in a stronger in vivo anticoagulant effect.
• Target Antigen: VD/VDR
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/r-acenocoumarol.html
• Smiles: O=C1C([C@@H](C2=CC=C([N+]([O-])=O)C=C2)CC(C)=O)=C(O)C3=CC=CC=C3O1
• Molecular Weight: 353.33
• References & Citations: [1]Ufer, et al. Comparative pharmacokinetics of vitamin K antagonists warfarin, phenprocoumon and acenocoumarol. Clin. Pharmacokinet. 44(12), 1227-1246 (2005).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported